Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats
نویسندگان
چکیده
منابع مشابه
The physiological role of liver alcohol dehydrogenase.
1. Yeast alcohol dehydrogenase was used to determine ethanol in the portal and hepatic veins and in the contents of the alimentary canal of rats given a diet free from ethanol. Measurable amounts of a substance behaving like ethanol were found. Its rate of interaction with yeast alcohol dehydrogenase and its volatility indicate that the substance measured was in fact ethanol. 2. The mean alcoho...
متن کاملInfluence of Genetic Variation in Alcohol Dehydrogenase
RESULTS—Moderate to heavy alcohol consumption ( 5 g/day for women and 10 g/day for men) was associated with a decreased risk of diabetes among women (odds ratio [OR] 0.45 [95% CI 0.33–0.63]) but not men (1.08 [0.67–1.75]). ADH1C genotype modified the relation between alcohol consumption and diabetes for women (Pinteraction 0.02). The number of ADH1C*2 alleles, related to a slower rate of ethano...
متن کاملKinetic studies of liver alcohol dehydrogenase.
1. NADH2 prepared by enzymic reduction of pure NAD by the method of Rafter & Colowick (1957), and isolated as the sodium salt, gives higher maxrimum rates of reduction of acetaldehyde with liver alcohol dehydrogenase at pH 6 than a number of commercial preparations of high purity. Maximum values of 2-4 for the extinction ratio E260/E340 and 2% for the proportion of inactive material absorbing a...
متن کاملAlcohol Abuse and Oral Cancer
Background: Various medical, psychiatric and social problems affecting alcohol abuser tend to overshadow their oral health. From an epidemiologic viewpoint, chronic consumption of alcoholic beverages is associated with an increased risk for the upper gastrointestinal tract cancer, and tobacco and alcohol are regarded as the major risk factors for oral cancer. The objective of this presentation ...
متن کاملMeta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease.
The purpose of this paper is to assemble and evaluate existing data on the effect of genetic variation in ADH2 and ADH3 on the risk of alcohol dependence, and on the risk of alcoholic liver disease. Calculations of odds ratios and their confidence limits, and tests for heterogeneity of the results from the available studies, have been performed. It is clear that possession of the ADH2-2 allele ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1993
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1993.tb17715.x